Of course. The problem is that it's nearly impossible to know who is going to react.
Yesterday I had my dog immunized with the usual things. He is drug reactive and immune-suppressed. As the dr was sticking him I slapped my forehead and thought: I SHOULD have at least given these inoculations over a period of time. doh. Fortunately, today he is right as rain. Anyway, the rabies inoculation is for the good of the public health, not for his own good, that's for sure.