Catherine: What a great idea to spend some restorative time with DD!
I think the Berkshires could be described as soul-satisfying. There are wonderful gardens: The Mount, Berkshire Botanical Gardens, Naumkeag. There are excellent museums: The Clark, MA MOCA, Norman Rockwell (we haven't been to Rockwell but have heard good things). There are wonderful parks: Ashintully, Natural Bridge State Park, Mt. Greylock, Bash Bish Falls. Places we like to stay are Black Swan Inn (have to get a lakeview room), The Guest House at Field Farm, Oak n Spruce (timeshare resort, so they will try to sell you, but you can get good accommodations inexpensively in a nice area).
I also loved where we stayed last year at The Old Mill Inn in Hatfield MA. It's a very quiet town, but is just outside of Northampton which has a lots of nice shopping and dining options. We really enjoyed the greenhouses at Smith College, Magic Wings Butterfly Conservatory, and the Three Sisters Sanctuary.
If either of those areas seem appealing, I would be glad to answer any questions or provide more details.