Yes, it will be a nice change from the default charge of racism for every disagreement with the President to be accused of sexism for every thwarted power grab. If only for variety's sake.
While I'm hoping for a good deal of the right kind of "obstructionism" in the event of a Clinton Administration, I also believe she will be in a better position to actually compromise with the opposition. I don't think she has ever displayed the sort of ideological rigidity the current president has.